Chief at the Tribhuvan International Airport Raj Kumar Chhetri said the injured persons have been flown on a chopper to Kathmandu for treatment.
The crash occurred while the Summit Air plane was trying to take off from Lukla for Kathmandu, said aviation officials.
Kathmandu: At least two people were killed in Nepal when an airplane collided with a helicopter Sunday morning, according to local authorities. The dead include one of the pilots of the plane and two police officers who were near the parked helicopter.Police spokesman Uttam Raj Subedi said: "The co-pilot and a policeman died at the crash site".
Both are private airline firms that cater to tourists and Nepalese in the country's remote areas.
Summit Air's pilot Captain RB Rokaya and flight attendant R Lama are safe.
Lukla airport is the nearest airport to the world's highest peak Mount Qomolangma, while April-May is the peak climbing season in the Himalayan country.
Tenzing-Hillary Airport is known as the gateway to Everest and is regarded the world's most risky because of its hard approach and short runway. The airfield is notorious for its short runway and perilous approach, sitting at an elevation of over 2,800 meters.
It's believed a small plane crashed into a helicopter while taking off from an airstrip.