The President's comments refer to doctored images that surfaced on social media following his visit to Alabama, with multiple users claiming he traveled to the region with a body-double for the First Lady.
The president said the internet rumor was another example of "fake news".
A freaky claim that First Lady Melania Trump is sometimes replaced by another woman hidden behind large sunglasses and similar outfits resurfaced after Trump made a trip to the site of a deadly tornado in Alabama last week.
"When you're in college or high school, there is the pretty girl who is nice, and you go with the marker to mark up her locker and then you gossip about her and you call her names".
This theory/meme/genuine mystery was brought into the limelight once again this week, as one journalist went as far as to say that it was "100% not Melania Trump" who Trump could be seen holding hands with.
Co-host Brian Kilmeade remarked as an aside, "There's no one that has the president's back like the first lady".
Ironically, it seems the First Lady herself is a fan of conspiracy theories.
"I've always found it sad that a group of women spend so much time attacking another woman, whose only goal is to help children", Grisham wrote.
Trump expressed similar disdain for fake news hits on the first lady in an exclusive interview with Breitbart News this week.
Several factors can influence the way people appear in photos, including the angle at which the photos are taken, the type of camera lens that is used and the positioning of the photographer, said Akili Ramsess, executive director of the National Press Photographers Association.