A Cessna 414A crashed in a residential area of Yorba Linda, California, killing two people and injuring two others on Sunday afternoon.
"[Total of] 1 structure involved, 2 people dead, 2 patients transported to local hospital", the statement, posted on Twitter, read.
A house destroyed by flames is seen shortly after a small plane crash in Yorba Linda on February 3, 2019.
The number of people in the plane are unknown. A Cessna 414A, depending on its configuration, is capable of carrying up to 10 people.
The Orange County Fire Authority said crews ultimately responded to two homes which had caught on fire.
Local residents described a shrill whistling sound before an explosion set the two-storey home on fire at 13:45 (21:45 GMT) on Sunday.
He said the deceased occupants of the home were two males and two females.
The Federal Aviation Administration and National Transportation Safety Board are now investigating.
Clint Langford, another neighbor, recalled hearing a low rumbling sound right before the crash.
The main body of the twin-engine plane was found in the backyard of another home not far from the burned house.
Images also showed a propeller and other debris scattered across a driveway.
The Orange County Coroner is working to positively identify those who died and notify next of kin, the sheriff's office said.