LeBron will not have a minutes restriction, per coach Luke Walton, who added that the Lakers will keep a "close eye" on their superstar's conditioning considering he has been out for the last 17 games.
"Worked my ass off to get back to this point", James said.
James, who missed the previous 17 games due to a groin injury sustained in a Christmas night win against the Golden State Warriors, also matched his season high with 14 rebounds and distributed nine assists while playing 40 minutes.
Showing no sign of the injury that resulted in the longest absence of his 16-year career, LeBron James made a triumphant return to the court.
The Lakers went 6-11 during James' absence and fell out of a potential playoff spot.
"I'll gain my rhythm as the season continues, and I'm looking forward to seeing how I feel tomorrow".
He added: "This is where I can shut out everything, be out there with my guys, command my guys, and get a win on the road".
Fortunately for them, Lance Stephenson continued to make timely shots and finished with 20 points while tying a career-high with five 3-pointers.
James has not played in nearly five weeks as he injured his groin against the Golden State Warriors on Christmas Day.
Lou Williams scored 24 points off the bench to lead the Clippers, who had won 22 of their previous 25 matchups against the Lakers.
James told ESPN's Dave McMenamin that with the team having slipped out of play-off contention while he was sidelined, they had one message - that they "were all ready to make this push". Expect a revived and refreshed team in the coming days now that this all-timer is back in the fold.