And with the performance, Messi has succeeded in sending Ronaldo's 105 strikes for Real Madrid, which previously stood as the most Champions League goals for one club, to the archives.
Messi has now scored 10 goals in five Champions League matches against Dutch opponents, including his hat trick against PSV in their Group B opener this season.
Mark van Bommel is hopeful of a victory against Barcelona on Wednesday which would keep PSV's hopes of a Europa League place alive. "In the first half, we lost a lot of easy balls".
Since France Football released their thirty-man shortlist for the award, speculation around both Lionel Messi and Cristiano Ronaldo's snub from the top three spots have been rife, with RFI journalist Eric Mamruth claiming that the top three spots will instead be filled by Luka Modric, Raphael Varane and Kylian Mbappe.
The Argentine now needs to get 78 more goals for Barcelona so as to reach the total by Pele which is quite possible considering his scoring form up to now.
The home side had the best chances of the first half as de Jong´s shot hit the cross bar and defender Denzel Dumfries´ follow-up re-bounded off the post moments before the break. Dembele scored Barcelona's lone goal against Atletico, his seventh goal in all competitions.
Malcom then turned a low Dembele cross wide of the post in the 73rd minute, before Bergwijn just missed the post down the other end during an open period of the match.
Luuk de Jong's 83rd-minute header came too late. We knew we couldn't do that because they're a strong side.
Barcelona should have scored a third in the final exchanges when Messi released Malcom, but the substitute fired over the crossbar as it ended 2-1 on the night.