Messi ran amok at Wembley Stadium, slicing Spurs apart with incisive passes from deep, such as the one that allowed Philippe Coutinho to open the scoring, and was as unsafe as ever in front of goal, firing in the final two goals to end their winless run of three games.
Mauricio Pochettino certainly called it when, the day before his side met Barcelona at Wembley, the Tottenham manager admitted he could not find a solution for dealing with Lionel Messi and that he just told his players to relish the experience of facing against arguably football's greatest-ever player.
As the case was with the 2 goals scored by Kane and Lamela in the second half.
"Messi had more space in the second half and that is hard to stop", Pochettino said. But what was it like to play against him?
He scored one on that occasion, but he made it two against Spurs by burying a chance following another Suarez dummy in the 90th minute.
He also loves to play against Premier League teams, as he's scored more goals and provided more assists versus English teams than against teams from any other nation in European competitions.
In recent weeks there have been murmurs that Barcelona have been struggling after three games without a win in La Liga.
Now Barca looks to have a foot into the next round, but Spurs are in trouble.
Barcelona were vulnerable so they said, but on a pitch scarred from hosting British heavyweight champion Anthony Joshua's fight against Alexander Povetkin they took only two minutes to catch Spurs in the solar plexus. He rushed off his line to pressure Jordi Alba, who cut back for Coutinho.
Coutinho performed a minor miracle to keep the ball in play on the byline with Rakitic launching himself into a sensational 20-yard volley that clipped the post on its way into Lloris' net.
The main area Barcelona can improve is defensively.
Spurs did manage to carve out a couple chances as the half went on, but the LaLiga outfit did well to preserve their lead as they headed into the break.
Lamela's deflected strike wrongfooted Ter Stegen and ensured a fantastic finale but, with Spurs committing men forward, Alba seized on a loose pass to set up Messi to sweep home his second.
In Naples, a late goal from Insigne gave Napoli a lone goal win over Napoli while Inter Milan, the other Italian team in action on Wednesday also secured victory; beating PSV 2-1 away from home.
Spurs pushed hard for the equaliser and almost had it in the 84th minute when Lucas Moura broke free in the Barcelona area only to see his shot from 8 yards out deflect off Lenglet and out of touch.
But the damage was done due to defensive errors from Lloris and Sanchez as they badly missed Vertonghen's calming influence and Dembele's presence in front of the back four.