Resuming at 76 for three after lunch, the visitors quickly found themselves on the back foot as all rounder Ben Stokes picked up two wickets to leave India reeling at 100-5 and trailing England's first innings total by 127 runs.
The first three wickets fell for eight runs as they slipped to 3-216 with Root's misfortune accompanied by a full-house "send-off" from his opposite number Virat Kohli.
The day certainly belonged to Kohli, whose dogged determination for a course correction was evident during an innings where he scored more than fifty percent of his team's runs even as he was booed by England fans for his version of "mic drop" celebrations on the first day.
Curran used conditions to good effect as he trapped Vijay leg before, got KL Rahul (4) to play a lazy shot and then Dhawan edged one to the slip cordon.
He claimed his fourth scalp later in the afternoon session as India, like England, were bowled out fairly cheaply after an assured start.
Jennings left after the lunch break scoring 42 runs. Kohli played all the five matches in 2014 but managed just 134 runs in the series at an average of 13.40. It is a manifesto of what they are going to achieve, by bending opponents to their will; and, unlike politicians, they usually adhere to it. Kohli announced that he can score red-ball runs in England in spite of James Anderson's stated belief.
Off-spinner Ravichandran Ashwin took four wickets for 60 runs in 25 overs while paceman Mohammed Shami had two for 64 in 19.
India made 274 before England lost Alastair Cook to the day's final ball as they closed on 9-1 - a lead of 22.
Now England are playing their 1000th Test at Edgbaston in Birmingham under the captaincy of Joe Root against India. "I was working on simplifying my actions a bit and make sure I can get more body into the ball, try create something in the air and it worked really well", he said. The five-match Test series saw Kohli dismissed six times behind the stumps to a probing off stump line.
Root top-scored with 80 before falling run out. "Whatever difficulties I face, I first wanted to play cricket and keep doing it, and the result is in front of us", he further added.
Vijay was the first to fall for 20 as Curran swung the ball back into his pad and won a leg before review.