Cavani's brace in Uruguay's 2-1 win in Sochi took his tournament tally to three goals and condemned Portugaltalisman Cristiano Ronaldo to a World Cup exit, just hours after his great rival Lionel Messi took the same path.
Cavani headed home before the break and, soon after Pepe had headed a second-half equaliser, scored the victor with a superb curling shot.
Cristiano Ronaldo became the second big name player to crash out of the World Cup today after Portugal were beaten 2-1 by Uruguay.
Ronaldo was involved somewhat in Portugal's goal, even if he didn't come close to getting a touch on the cross.
At 33, many feel we have seen the last of Ronaldo the World Cup, although the player himself shunned questions on the issue after the defeat against Uruguay.
Uruguay coach Oscar Tabarez was complimentary of Ronaldo and the rest of the Portugal squad, noting several times Uruguay will be facing the reigning champions of Europe. Mulsera makes a howler, dropping the ball.it falls to Bernardo Silva who panics and blazes his shot over the bar with the goal gaping.
Uruguay played a ideal group stage against relatively weak opponents to make it to the Round of 16, but the South American side proved it has what it takes to make a deep run at the World Cup by sending the reigning European champions home on Saturday.
Despite the exchanges often becoming heated, Uruguay striker Suarez claims that any ill feeling towards Portuguese star Ronaldo is limited to club matches and not the global stage. With the "Fubo Premier" bundle, you will get access to all four of the World Cup soccer TV channels in most markets.
Portugal will be disappointed with their performance against Uruguay after boasting nearly 70 per cent of possession and firing off 20 shots.
Uruguay: Muslera 7, Gimenez 8, Godin 8, Laxalt 7, Caceres 6, Bentancur 6, Nandez 6, Torreira 6, Vecino 6, Suarez 8, Cavani 9.
Cavani switched play with a long cross to Luis Suarez and continued his run to head home a pinpoint deep cross from the Barcelona forward and give Uruguay a seventh-minute lead.