Matip, who missed the final two months of last season with a thigh problem, lasted just 22 minutes of the Reds' 3-1 defeat in North Carolina.
Virgil van Dijk pulled off a magnificent header from the edge of the six-yard box, supplied by Andrew Robertson following a short corner by Rafael Camacho. Dortmund tried to play football and played our cards, if you want, which helps us a little bit to do this.
Pulisic has spent his entire career with Dortmund, and has racked up an impressive 12 goals and 20 assists in 97 appearances in all competitions.
Speaking before the game, Matip admitted he had yet to return to full fitness and was hoping it would present another step to recovery. "I watched the games, I lead the sessions and then I make a decision at a specific point but that's not today and it's not next week so we still have time", Klopp was quoted by Echo.
While a third supporter questioned if he was still having health issues.
But against Liverpool, the German side were poor in front of goal with no one able to put much pressure on the Reds' defence when their wide players had broken through - despite being saved by Pulisic after his arrival.
'He is the No.1 for Brazil and then there is the fee.
He was involved in all three of Dortmund's goals, scoring two before cutting inside to lash an effort at Loris Karius and forcing the German to spill the ball to the feet of the waiting Jacob Bruun Larsen.
Deep into stoppage time, the US worldwide beat his defender in the box and Loris Karius parried his shot into the path of Jacob Bruun Larsen, who finished into an empty net.
Dortmund came into the clash on the back of a 1-0 win over Manchester City on Friday evening, with Mario Gotze netting the victor.