Wimbledon champion Angelique Kerber said that it was "amazing" to become the first German player to claim the Venus Rosewater dish since Steffi Graf in 1996.
"I think I'm the next one after Steffi who won - it's unbelievable", Kerber, 30, said after the match.
Williams was aiming to match Margaret Court's record of 24 grand slam singles titles after a remarkable run just 10 months on from the birth of her first child.
"So I think these two weeks have really showed me that, okay, I can compete".
"To all the moms out there, I was playing for you today - and I tried", said the 36-year-old American, her voice shaking during the trophy ceremony.
In a role reversal from her wedding - at which Williams was a guest in May - Markle is watching her friend from the royal box.
"Without 2017, I couldn't win this tournament", Kerber said. I saw her at the beginning of the tournament where I don't think she played well. It is Djokovic's first final at the All England Club against someone other than Roger Federer, Rafael Nadal or Andy Murray.
As things stand, Williams holds the mark for the half-century of professional tennis, one ahead of Kerber's idol, Graf.
"To share with her a court, it's always an honor for me because I know she's pushing me to the limits I have to play my best tennis". 'It's unfair to say, Kerber is playing very nicely, but it doesn't matter to me.
The head-to-head numbers (Williams leads 6-2) can sometimes distract from the real narrative. Her scar ruptured due to coughing and she was taken into surgery, but when doctors opened her up, they found a large hematoma in her abdomen.
"Unfortunately, in the "90s, they changed the rule whereas if you were injured - then you come back, you lose your seeding", Williams told ABC News" Good Morning America during an interview last month in New York City.
Alexis Ohanian posted a photo of the tennis champion onto Instagram with the caption "just getting started". In 2017, overwhelmed and overscheduled, Kerber failed to advance out of the fourth round of a major, dropped out of the top 20 and fired her longtime coach.
Serena Williams finished as a runner-up to Angelique Kerber during the women's final at Wimbledon on Saturday.
He went on to write that he has complete faith in her future victories, and the most important trophy of all was waiting at home - their daughter Alexis Olympia Ohanian Jr.
Also advanced to quarter-final at Roland Garros and Wimbledon semi-finals, where she lost to Agnieszka Radwanska.
"It was only her 14th match back". I think to make again such a year is impossible. The fact we have two Grand Slam champions going for another Wimbledon title is going to be lovely.