Kimmich's charging runs far up the field can be a blessing and a curse for Germany.
But right from the first minute, or even right from the national anthems, it seemed this opener could be different.
Rather than get a nose bleed, Lozano was as cool as a cucumber, cutting inside and rifling the ball past a hapless Manuel Neuer.
Mexico introduced Rafael Marquez - who is featuring at his fifth World Cup - but it did not halt constant pressure from Germany, with Kroos curling just wide from 20 yards and substitute Edson Alvarez denying Draxler with a timely block.
Mexico is not the clear favorite in Group F but they will definitely try to take avenge of the 4-1 defeat against Germany on their last encounter.
Another said: "Germany look like they could do with a certain Leroy Sane".
Germany dominated the second half proceeding, but they couldn't find the final touch that would lead to a goal.
Lozano reveled in the space left for him on Mexico's left flank and was a constant threat on the counterattack. Hernandez finds himself one-on-one with Boateng, and he opts to slide it over for Lozano, who cuts inside before tucking it past Neuer at the near post. Wow.
Mexico has only ever beaten Germany once in 11 tries and that win came way back in 1985.
Mexico were the more composed side, though, and they also had speed and willing runners.
A Herving Lozano goal in the first half proved priceless for a team that has played four times already with the European giants at the World Cup but was yet to record a victory.
Minutes later, Germany were within a whisker of an equaliser when Kimmich's pullback was met by a Kroos strike that whistled past the post before Kroos found Draxler, who stepped away from one defender but had his strike blocked by another.
Mexico had - and wasted - a breakaway chance to seal the game, Layun blasting wide before the frustrated Muller and Hummels were booked for fouls in quick succession.