Forty-three of the attacking militants were killed and six vehicles were destroyed, the ministry said.
On Sunday, Tass, citing a defense ministry statement, said "a few mobile terrorist groups" attacked an artillery battery belonging to Syrian government forces for one hour at undisclosed time.
In Syria in an attack by ISIS militants killed nine Russian soldiers and 26 fighters of the Syrian army of the regime of President Bashar al-Assad.
A war monitoring group however, has put the death toll of Russian forces at nine. They said some, but not all of the Russians were troops.
The remaining 26 have been all Syrian forces, he advised AFP.
Russian Federation is the main military backer of Syrian President Bashar al-Assad in his country's multi-sided civil war.
Russian Federation did not specify when, where, or whether IS was involved, but it appeared to be the same incident as the IS attack reported near Mayadeen.
Two Russians who had been helping to direct Syrian artillery fire were killed during the fighting, the report added, and two others died later as a result of wounds suffered during the battle. According to official numbers 92 russian military personnel have died in Syria since Moscow's intervention in the conflict.
All this could bring Russian Federation and the United States to the bloody conflict but pro-Syrian government lost the battle.
Russian Federation has been a staunch backer of Syrian President Bashar al-Assad.
He was part of a group of military instructors who were training Syrian soldiers.
The very best casualties have been in March, when a transport airplane crashed at Hmeimim airbase the place Moscow's airforce is predicated, killing all 39 individuals on board.
Russian ministry said that 43 rebels had been killed in the same fighting.