The former world number one briefly returned for the American hardcourt season, but suffered early losses to sister Venus and Naomi Osaka in Indian Wells and Miami respectively.
Williams then took another break to work on her game, and that absence of more than two months ended Tuesday.
"I think if there is any way to turn that match around, it's that way", she said. Interviewed by Reuters, the 18-time Grand Slam victor, who will work as a commentator for ESPN in Paris, said Sharapova 'has a shot" at the title. "I see her moving better and the intensity is back.
Azarenka herself wasn't given a seeding at Wimbledon past year after returning to the game following the birth of her son.
"And Wimbledon has the choice to do that".
"So if we talk in terms of rule, the rule has to be for everybody". Both are huge servers, but Pliskova leads the WTA tour with the record for most aces in a match (31).
The 36-year-old got off to a winning start in straight sets over Kristyna Pliskova.
Heavy rain halted the champion's progress on Monday evening with him leading 6-4, 6-3, 0-3 against Italian lucky loser Simone Bolelli.
Williams, unseeded in the draw, takes on No. 17-seeded Ashleigh Barty in the second round.
Two-time French Open champion Maria Sharapova of Russian Federation was pushed to three sets in her return to this event following a two-year absence. She's ranked No. 451 coming into the French Open.
After a 90-minute rain interruption at 5-5 in the first set Muguruza, the 2016 victor, blew 2009 champion Kuznetsova away in the tie break and went on to win 7-6 (7-0) 6-2.